Possible Interaction: Tocotrienols and Tocopherols

“Recently, it has been suggested that the biological effects of tocotrienols may differ from that of tocopherols.”

“The results of several studies have indicated that the tocotrienols may have a stronger bioactivity than the tocopherols.”

“The exact reason why tocotrienols are more potent than tocopherols is not completely understood, but at least part of the reason is because of greater cellular accumulation.”

“ Tocotrienols have been reported to have higher biological activities than tocopherols.”

“Although the antioxidant activity of tocotrienols is higher than that of tocopherols , tocotrienols have a lower bioavailability after oral ingestion.”

“Although the tocopherols and tocotrienols are closely related chemically, they have widely varying degrees of biological effectiveness.”

“… tocopherols … tocotrienols have been reported to differ in their physiological functions, including their antioxidant and apoptotic activity.1,2 The tocotrienols are known to affect organizational …-omega-hydroxylase cytchrome P450 enzyme (CYP4F2)4 and have observed the inhibitory effects of the tocotrienols on their own metabolism at high concentrations.”

“The present study suggests the occurrence of a high degree of biodiscrimination between tocopherols and tocotrienols during the development of the chick embryo.”

“These data clearly show that TPs can be discriminated from TTs according to their structure.”