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Discover Supplement-Drug Interactions

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Last Updated: 2 years ago

Possible Interaction: Tobramycin and Calcium Supplement

Research Papers that Mention the Interaction

Physiologic concentrations of calcium in serum antagonize the activities in vitro of gentamicin and tobramycin on Pseudomonas aeruginosa.
Chemotherapy  •  1973  |  View Paper
Studies were carried out to determine whether tobramycin , a new aminoglycoside antibiotic, is also antagonized by calcium.
The activity of tobramycin in vitro was shown to be antagonized by human serum and by physiological concentrations of calcium.
Antimicrobial Agents and Chemotherapy  •  1972  |  View Paper
Abstract— Tobramycin , like other aminoglycoside antibiotics, is a basic compound which causes a reduction of cardiac contractile force and inhibits the inotropic action of calcium.
These results suggest a competitive type of antagonism, between the ionized fraction of tobramycin and calcium , for superficial sites of the sarcolemma.
The Journal of pharmacy and pharmacology  •  1989  |  View Paper
The aminoglycoside antibiotics, neomycin, gentamicin, tobramycin , kanamycin, amikacin, netilmicin, as well as neamine and spectinomycin (all at 0.1 mM) showed a graded effect on the rate of carboxyfluorescein release from PIP2-containing vesicles in the presence of 0.1 mM calcium.
Biochimica et biophysica acta  •  1987  |  View Paper
Calcium and magnesium ions inhibited the bactericidal effect of tobramycin.
Antimicrobial Agents and Chemotherapy  •  1972  |  View Paper