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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Tobramycin
supplement:
Calcium Supplement
Research Papers that Mention the Interaction
“Physiologic concentrations of calcium in serum antagonize the activities in vitro of gentamicin and tobramycin on Pseudomonas aeruginosa.”
Relative antagonism in vitro of calcium in serum to the bactericidal activities of gentamicin and tobramycin on Pseudomonas aeruginosa.“Studies were carried out to determine whether tobramycin , a new aminoglycoside antibiotic, is also antagonized by calcium.”
“The activity of tobramycin in vitro was shown to be antagonized by human serum and by physiological concentrations of calcium.”
“ Abstract— Tobramycin , like other aminoglycoside antibiotics, is a basic compound which causes a reduction of cardiac contractile force and inhibits the inotropic action of calcium.”
“These results suggest a competitive type of antagonism, between the ionized fraction of tobramycin and calcium , for superficial sites of the sarcolemma.”
The influence of pH on the cardiac depressant action of tobramycin“The aminoglycoside antibiotics, neomycin, gentamicin, tobramycin , kanamycin, amikacin, netilmicin, as well as neamine and spectinomycin (all at 0.1 mM) showed a graded effect on the rate of carboxyfluorescein release from PIP2-containing vesicles in the presence of 0.1 mM calcium.”
Aminoglycoside antibiotics preferentially increase permeability in phosphoinositide-containing membranes: a study with carboxyfluorescein in liposomes.“ Calcium and magnesium ions inhibited the bactericidal effect of tobramycin.”
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