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Possible Interaction: Tizanidine and Yohimbine



Research Papers that Mention the Interaction

Idazoxan (I1, I2, I3, and alpha2), efaroxan (I1, I3, and alpha2), and RX821002 (I3 and alpha2), but not yohimbine , an alpha2-adrenergic receptor antagonist with no affinity for I receptors, antagonized the inhibitory effects of tizanidine.
Journal of pharmacological sciences  •  2005  |  View Paper
In the second part of the study, after pretreatment with yohimbine , an alpha-2 adrenergic receptor blocker, at the dose of 2 mg/kg, anticonvulsant effect of tizanidine is diminished.
General pharmacology  •  1999  |  View Paper
The blockade of alpha 2-adrenoceptors with yohimbine or phentolamine counteracted the protection induced by tizanidine.
Pharmacology & toxicology  •  1999  |  View Paper
These effects of TIZ on M-dependent ileum were antagonized by the alpha 2-adrenoceptor antagonist yohimbine.
Pharmacology Biochemistry and Behavior  •  1992  |  View Paper
Exposure of the cord … microM clonidine and tizanidine significantly reduced the release of substance P. The inhibitory effects of clonidine and tizanidine were attenuated by pre-exposure of … 10 microM piperoxane, which has alpha 2-antagonistic activity and the inhibitory effect of clonidine was attenuated by 10 microM yohimbine.
Neuropharmacology  •  1991  |  View Paper
The action of tizanidine was antagonized by the alpha 2-adrenoreceptor antagonist, yohimbine , but not by the alpha 1 antagonist prazosin, nor by dopamine, serotonin and GABA receptor antagonists.
Neuropharmacology  •  1987  |  View Paper
The action of tizanidine and clonidine was completely antagonized by pretreatment with yohimbine , an alpha 2-adrenoceptor blocker, but not by prazosin, an alpha 1-adrenoceptor blocker.
European journal of pharmacology  •  1986  |  View Paper
Yohimbine and phentolamine reduced the inhibition of TRH-stimulated acid secretion by tizanidine.
Archives internationales de pharmacodynamie et de therapie  •  1985  |  View Paper
The preferential depressant actions of tizanidine , noradrenaline and clonidine were antagonized by the selective alpha 2-antagonist RX781094 administered iontophoretically at the same site as the agonists, and by intravenously administered yohimbine.
Neuroscience  •  1985  |  View Paper
Pretreatment with the alpha 2-blocker yohimbine antagonized the depressant action of tizanidine in intact rats whereas the alpha 1-blocker prazosin antagonized the facilitatory action of tizanidine in the spinalized rats.
Neuroscience  •  1987  |  View Paper