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Last Updated: 3 years ago
supplement:
Tyrosine
Research Papers that Mention the Interaction
“Other investigators have shown that TPA treatment of SH-SY5Y cells results in increased tyrosine phosphorylation of cytoskeletal-associated proteins, including the adapter protein Cas.”
PKC-dependent activation of FAK and src induces tyrosine phosphorylation of Cas and formation of Cas-Crk complexes.“ tPA rapidly induced tyrosine phosphorylation of focal adhesion kinase (FAK), which led to activation of its downstream mitogen-activated protein kinase signaling.”
tPA is a potent mitogen for renal interstitial fibroblasts: role of beta1 integrin/focal adhesion kinase signaling.“Furthermore, tPA induced rapid tyrosine phosphorylation on the β subunit of LRP-1, which was followed by the activation of Mek1 and its downstream Erk-1 and -2.”
“ATP‐ and TPA‐stimulated activation of p42 MAPK activity and tyrosine phosphorylation were inhibited by long‐term TPA treatment, while A23187‐stimulated effects were completely blocked.”
“Since some mitogenic hormones stimulate a tyrosine-specific protein kinase activity, and since the transforming protein of RSV is a tyrosine-specific protein kinase, we have examined whether TPA also stimulates protein phosphorylation on tyrosine.”
“We report here that TPA treatment of normal cells resulted in a very rapid phosphorylation on tyrosine of a protein peak of Mr 40 to 43 kilodaltons.”
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