“In addition, TSC plus tPA administered 3 h following embolization significantly (p<0.05) increased the group P(50) value by 90%.”
“In combination studies, when TSC was administered 1 h and tPA was given either 1 or 3 h following embolization, the group P(50) values were increased by 291% and 140%, respectively.”
“This study suggests that TSC may be used for the treatment of AIS either alone or when administered before or concomitant with tPA to improve clinical rating scores with a therapeutic window for TSC therapy up to 3 h in rabbits.”