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Discover Supplement-Drug Interactions

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Last Updated: 2 years ago

Possible Interaction: Tissue Plasminogen Activator and Silymarin

Research Papers that Mention the Interaction

Topical application of silymarin on mouse skin prior to that of TPA or OA resulted in a highly significant to complete inhibition in a dose-dependent manner against both TPA- and OA-caused induction of TNF alpha mRNA expression in mouse epidermis.
Biochemical and biophysical research communications  •  1997  |  View Paper
Application of silymarin at doses of 0.5-18 mg (1-37 mumol)/mouse prior to that of TPA (2.5 micrograms) treatment resulted in significant inhibition of TPA-induced epidermal ODC activity in a dose- and time-dependent manner.
Carcinogenesis  •  1994  |  View Paper