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Discover Supplement-Drug Interactions

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Last Updated: 3 years ago

Possible Interaction: Tissue Plasminogen Activator and Serine

Research Papers that Mention the Interaction

In addition, the enhanced incorporation of serine by TPA into its corresponding phospholipid implies the stimulation of the serine base exchange enzyme which is responsible for phosphatidylserine synthesis in mammals.
The Italian Journal of Neurological Sciences  •  2006  |  View Paper
The substitution of serine for alanine at position 473 substantially reduced the slow inactivation that occurs at pharmacological levels of t-PA in plasma.
Thrombosis and haemostasis  •  1996  |  View Paper
In spite of their differences on transport, TeTx, TPA and NGF produce an increase in serotonin transporter phosphorylation in Ser separately, which is abolished by the PKC-inhibitor bisindolylmaleimide-1.
Neurochemistry International  •  2003  |  View Paper
Although Ser‐62 phosphorylation was not affected by TPA, phosphorylation at a different serine residue was significantly upregulated by TPA.
Journal of cellular biochemistry  •  1999  |  View Paper
Moreover, TPA regulated the affinity of both wild-type and mutant receptors and stimulated receptor phosphorylation of serine and threonine residues other than Thr-654.
Molecular and cellular biology  •  1988  |  View Paper
In addition, TPA treatment resulted in rapid changes in phosphorylation of proteins on serine and threonine.
Biochemical and biophysical research communications  •  1983  |  View Paper