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Last Updated: 2 years ago

Possible Interaction: Tissue Plasminogen Activator and Progesterone

Research Papers that Mention the Interaction

However, Northern blotting analysis demonstrated that progesterone strongly down-regulated (up to 60-fold) the gene expression of urokinase plasminogen activator and increased (up to 5-fold) the expression of tissue-type plasminogen activator in these cells.
Clinical cancer research : an official journal of the American Association for Cancer Research  •  2001  |  View Paper
The phorbol ester TPA , and basic fibroblast growth factor, dramatically suppress cAMP-induced production of progesterone , whereas bovine corneal endothelial cell ECM (BCE/ECM) enhanced cAMP-induced progesterone and antagonized basic fibroblast growth factor suppression of cAMP-induced steroidogenesis.
Endocrinology  •  1998  |  View Paper
Blockade of progesterone signaling by TPA for 24 h results in fewer cells in G2/M, attributable to decreased expression of genes that facilitate the G2/M transition.
Gene expression data suggest that TPA affects several mechanisms that progesterone utilizes to control gene expression, including specific post-translational modifications, and nucleosomal organization and higher order chromatin structure, which regulate access of PR to its DNA binding sites.
BMC Cancer  •  2016  |  View Paper
Various agents that stimulate cellular protein phosphorylation (8-Br cAMP, okadaic acid, TPA ) functionally synergize with progesterone to enhance progesterone-dependent PRtrans-activation in intact cells.
Breast Cancer Research and Treatment  •  2004  |  View Paper
Conversely, progesterone withdrawal reduces TF and PAI-1 expression and increases tPA , uPA, MMP, and ET-1 expression accounting for the hemorrhage, enhanced fibrinolysis, ECM degradation, and ischemic spiral arterial vascular injury characterizing menstruation.
The Journal of the Society for Gynecologic Investigation: JSGI  •  1996  |  View Paper
In a primary human … culture, the addition of progesterone resulted in an approximately 2-… in the amount of tissue-type plasminogen activator (t-PA) released into the culture media, with the minimal effective dose being 10(-…. In contrast, progesterone significantly reduced the release of urokinase-type PA (u-PA).
Endocrine journal  •  1995  |  View Paper
In addition, while TPA inhibited the PMSG and forskolin induced-accumulation of progesterone in the media, the gonadotropin and forskolin inhibited the elevation of PGE2 levels evoked by TPA (a dose dependent decrease of 35-55%).
General and comparative endocrinology  •  2018  |  View Paper
The study concluded that PROG may extend the time window for tPA administration in ischemic stroke and reduce hemorrhagic conversion.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism  •  2014  |  View Paper
Moreover, this response was inhibited by the PKC inhibitor H7, the PKCα specific inhibitor Gö‐6976 and the … cycloheximide, but not by the transcription inhibitor actinomycin D or the replication inhibitor mitomycin C. In addition, TPA also reversed the MMP‐… expression after by progesterone pretreatment in the … decidual cells.
Journal of cellular biochemistry  •  2009  |  View Paper
Co-treatment with forskolin and TPA decreased progesterone and P450scc mRNA levels as compared to forskolin treatment alone.
Molecular and Cellular Endocrinology  •  1993  |  View Paper
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