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Discover Supplement-Drug Interactions
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Last Updated: 2 years ago
supplement:
Polyphenols
Research Papers that Mention the Interaction
“Moreover, phosphorylation of p38 mitogen-activated protein kinase in ICR mouse skin, measured 4 h after TPA treatment, was suppressed by oral pretreatment of CP (40 or 200 mg/kg).”
Cocoa polyphenols inhibit phorbol ester-induced superoxide anion formation in cultured HL-60 cells and expression of cyclooxygenase-2 and activation of NF-kappaB and MAPKs in mouse skin in vivo.“Application of grape polyphenolics (20 mg) at 60 and 30 min prior to treatment with TPA inhibited ODC activity by 62 and 68%, respectively, compared with controls (P<0.05).”
“Collectively these data suggest that the grape polyphenolic fraction is effective as an inhibitor of ODC activity when applied before TPA , and that the magnitude of inhibition is independent of epidermal ODC protein content.”
Inhibition of 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced mouse skin ornithine decarboxylase and protein kinase C by polyphenolics from grapes.
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