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Discover Supplement-Drug Interactions

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Last Updated: 2 years ago

Possible Interaction: Tissue Plasminogen Activator and Masoprocol

Research Papers that Mention the Interaction

It was found that CsA‐resistant proliferative responses induced by direct PK‐C activators such as mitogenic concentrations of the phorbol ester TPA or the putative anti‐tumour agent bryostatin 1 (bryo 1) were inhibited in a concentration‐dependent manner by NDGA (IC50 = 2 μM).
Scandinavian journal of immunology  •  1996  |  View Paper
However, nordihydroguaiaretic acid , which blocks cyclooxygenase and lipoxygenases, potentiated the effect of TPA on proenkephalin mRNA, when used at concentrations of 0.5-50 mumol/l.
Brain research. Molecular brain research  •  1995  |  View Paper
Nordihydroguaiaretic acid (NDGA), a lipoxygenase inhibitor, abolished both the TPA and prolactin effects on [3H]uridine incorporation.
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine  •  1986  |  View Paper
Treatment of mice with nordihydroguaiaretic acid (10 to 90 mumol/mouse), a lipoxygenase inhibitor, also inhibited the induction of ODC by TPA.
Cancer research  •  1982  |  View Paper