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Discover Supplement-Drug Interactions
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Last Updated: 5 years ago
supplement:
Genistein
Research Papers that Mention the Interaction
“Pertussis toxin and genistein (inhibiting tyrosine kinase) significantly reduced the thrombin induction of both t-PA and PAI-1 (PTX: 142 +/- 23% and 146 +/- 19%, respectively, genistein: 156 +/- 42% and 76 +/- 24%, respectively).”
Thrombin signal transduction of the fibrinolytic system in human adult venous endothelium in vitro.“In contrast, the tyrosine kinase inhibitors herbimycin A and genistein inhibit the effect of TPA and staurosporine upon ctsl mRNA with little or no effect on c-jun expression.”
“It was demonstrated that PTK inhibitors such as genistein and herbimycin A modulated monocytic differentiation of HL-60 cells; they inhibited the differentiation induced by TPA , while promoting that induced by vitamin D3 (D3).”
“Based on the following observations, we conclude that the two pathways are different: (1) The effects are additive; (2) EGF induction of u-… inhibits the EGF effect and doubles the TPA induction of u-PA; (4) after EGF-induced tyrosine phosphorylations are completed, addition of TPA …, genistein , indicating … observed.”
“ Genistein but not cytochalasin D inhibited the SSC increasing action of TPA plus fibronectin or laminin.”
Regulation of acetylcholine release by extracellular matrix proteins at developing motoneurons in Xenopus cell cultures“Topical application of genistein 30 min before TPA treatment inhibits TPA-induced expression of these protooncogenes.”
Inhibitory effect of genistein on a tumor promoter-induced c-fos and c-jun expression in mouse skin.
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