Possible Interaction: Tissue Plasminogen Activator and Calcium Supplement

“Furthermore, CA was effective at reducing inflammatory damage induced by chronic TPA exposure.”

“The phorbol ester TPA was also effective in antagonizing W7's growth inhibition in low‐calcium DME, suggesting that the W7 effect is mediated via protein kinase C inhibition.”

“Combining CA 15.3 and CEA fails to increase CA 15.3 sensitivity, while combining CA 15.3 with TPA increases false-positives and so likewise offers no additional benefit.”

“Also, TPA inhibits the increased intracellular calcium promoted by ionomycin but not the increase promoted by anti-CD3 and ionomycin.”

“The results were as follows: 1) The membrane permeable cAMP analogue Bt2cAMP, the adenylate cyclase activator forskolin and the protein kinase C activator TPA all induced an increase in intracellular free calcium concentration.”

“The results showed as the simultaneous use of CA 125 and TPA can premise the diagnosis of ovarian cancer in high percentage.”

“The CA 15-3 and TPA association increased the sensitivity (87.2%), while the CEA and CA 15-3 association did not increase this parameter.”

“The presence of 10 μM calcium ions stimulates tPA activation of plasminogen 2-fold in an S100P-dependent manner.”

“The SPM PKC activity (both for endogenous substrate proteins and for histone), which was enhanced by TPA treatment of brain homogenate, was inhibited by calcium (IC50, 3 × 10−7M).”

“Treatment of splenocytes and lymph node cells of 5 month-old MRL/lpr mice with TPA induced IL-2-dependent proliferation of the cells in the presence of CA++.”