Allen Institute for Artificial Intelligence
supp.ai logo
supp.ai

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 2 years ago

Possible Interaction: Tissue Plasminogen Activator and Calcium Supplement

Research Papers that Mention the Interaction

Furthermore, CA was effective at reducing inflammatory damage induced by chronic TPA exposure.
Biological & pharmaceutical bulletin  •  2014  |  View Paper
The phorbol ester TPA was also effective in antagonizing W7's growth inhibition in low‐calcium DME, suggesting that the W7 effect is mediated via protein kinase C inhibition.
Journal of cellular physiology  •  1989  |  View Paper
Combining CA 15.3 and CEA fails to increase CA 15.3 sensitivity, while combining CA 15.3 with TPA increases false-positives and so likewise offers no additional benefit.
Breast Cancer Research and Treatment  •  2005  |  View Paper
Also, TPA inhibits the increased intracellular calcium promoted by ionomycin but not the increase promoted by anti-CD3 and ionomycin.
Archives of medical research  •  1996  |  View Paper
The results were as follows: 1) The membrane permeable cAMP analogue Bt2cAMP, the adenylate cyclase activator forskolin and the protein kinase C activator TPA all induced an increase in intracellular free calcium concentration.
Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae  •  1993  |  View Paper
The results showed as the simultaneous use of CA 125 and TPA can premise the diagnosis of ovarian cancer in high percentage.
Annali di ostetricia, ginecologia, medicina perinatale  •  1991  |  View Paper
The CA 15-3 and TPA association increased the sensitivity (87.2%), while the CEA and CA 15-3 association did not increase this parameter.
Minerva medica  •  1990  |  View Paper
The presence of 10 μM calcium ions stimulates tPA activation of plasminogen 2-fold in an S100P-dependent manner.
The Biochemical journal  •  2017  |  View Paper
The SPM PKC activity (both for endogenous substrate proteins and for histone), which was enhanced by TPA treatment of brain homogenate, was inhibited by calcium (IC50, 3 × 10−7M).
Journal of neurochemistry  •  1989  |  View Paper
Treatment of splenocytes and lymph node cells of 5 month-old MRL/lpr mice with TPA induced IL-2-dependent proliferation of the cells in the presence of CA++.
International archives of allergy and applied immunology  •  1987  |  View Paper
Show More