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Last Updated: 3 months ago

Possible Interaction: Tianeptine and Adrenocorticotropic Hormone

Research Papers that Mention the Interaction

Some antidepressant drugs, such as tianeptine , which were found to modulate ACTH release, appear to interfere with brain glutamatergic system.
Endocrine  •  2007  |  View Paper
Neuroendocrinology data showed that tianeptine decreases CRF and ACTH levels.
L'Encephale  •  1989  |  View Paper
Tianeptine , olanzapine and fluoxetine decreased the enhanced levels of plasma ACTH and IL-6.
Life sciences  •  2012  |  View Paper
In contrast, chronic administration of tianeptine (10 mg/kg twice a day for 15 days) induced a significant decrease in the concentration of corticotropin-releasing factor (CRF) in the hypothalamus and adrenocorticotropin (ACTH) in the anterior lobe of the pituitary.
Tianeptine abolished the stress-induced reduction of hypothalamic CRF concentration and markedly reduced the stress-induced increase in plasma ACTH and corticosterone levels.
European journal of pharmacology  •  1994  |  View Paper
The inhibitory effect of tianeptine on stress-induced elevations of plasma ACTH and corticosterone occurred from 1 to 3 h after the injection.
injection of tianeptine (10 mg/kg), 120 min before stress caused a significant decrease of ACTH and corticosterone levels.
European journal of pharmacology  •  1991  |  View Paper