supp.ai
Discover Supplement-Drug Interactions
Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 3 years ago
drug:
Tianeptine
supplement:
Adrenocorticotropic Hormone
Research Papers that Mention the Interaction
“Some antidepressant drugs, such as tianeptine , which were found to modulate ACTH release, appear to interfere with brain glutamatergic system.”
Control of ACTH secretion by excitatory amino acids“Neuroendocrinology data showed that tianeptine decreases CRF and ACTH levels.”
“In contrast, chronic administration of tianeptine (10 mg/kg twice a day for 15 days) induced a significant decrease in the concentration of corticotropin-releasing factor (CRF) in the hypothalamus and adrenocorticotropin (ACTH) in the anterior lobe of the pituitary.”
Effect of chronic treatment with the antidepressant tianeptine on the hypothalamo-pituitary-adrenal axis.“injection of tianeptine (10 mg/kg), 120 min before stress caused a significant decrease of ACTH and corticosterone levels.”
Help us improve supp.ai, we'd love to hear your feedback: Submit Feedback