Possible Interaction: Thyroxine and Tryptophan

“Double‐quenching experiments also showed that T4 produces changes in the tryptophans environments.”

“In some way, therefore, L-tryptophan has the power of promoting the adsorption of the virus T4 on its host.”

“Dietary supplementation with additional amounts of VE and tryptophan appears to reduce the decline of the production of T4.”

“It has been shown in compensatory hypertrophy of the thyroid gland of male rats …--240 g that of 18 compounds tested five drugs (cyclic AMP, theophylline, phenformin, tryptophan and disulfiram) reduce … effect of thyroxin and are likely to raise the threshold of … inhibition in the hypothalamohypophyseal and thyroid system.”

“It is found that theophylline, cyclic AMP, tryptophan , disulfiram and phenformin can raise the hypothalamo-pituitary threshold of sensitivity to homeostatic inhibition by thyroxine.”

“Both tryptophan and tyrosine reactivity increased when thyroxine was administered.”

“ Tryptophan inhibited the thyroxine effect, alone or in the presence of alanine or proline.”

“It has previously been reported that certain metabolites of tryptophane interfere with an action of thyroxine in vitro.”

“ L-Tryptophan is necessary for the adsorption of the T4 strain.”

“After it was found that the activation of T4 by L-tryptophan was strongly dependent on temperature (Anderson, 1948a), we undertook a brief study of the temperature dependence of plaque formation by T4 and T6 on minimal agar.”