Allen Institute for Artificial Intelligence
supp.ai logo
supp.ai

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 2 years ago

Possible Interaction: Thyroxine and Tretinoin

supplement:

Tretinoin

Research Papers that Mention the Interaction

While T4 alone did not stimulate miR-10a expression, the combination of T4 and ATRA was found to have a positive synergistic effect.
BMC Cancer  •  2015  |  View Paper
All-trans retinoic acid caused a similar shift in the emission spectrum of ANS, but was less potent than T4.
All-trans retinoic acid is a potent inhibitor of [125I]-thyroxine ( T4 ) binding to human erythrocyte membranes and can block the activation by thyroid hormone of erythrocyte Ca(2+)-ATPase [J. Biol.
Biochimica et biophysica acta  •  1994  |  View Paper
A concentration as low … 10(-10) M retinoic acid shifted the … of both T4 and T3 so that the concentration of each associated with maximal enzyme stimulation was 10(-9) M instead …(-10) M. Retinoic acid displaced [125I]T4 binding to red cell membranes as effectively as unlabeled T4.
These results indicate that retinoic acid can partially block the T4 and T3 stimulation of Ca2+-ATPase in human red cell membranes and suggest a physiologic role for the retinoid as a modulator of this peripheral action of thyroid hormone.
The Journal of biological chemistry  •  1989  |  View Paper