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Discover Supplement-Drug Interactions
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Last Updated: 2 years ago
drug:
Thyroxine
supplement:
Serum Albumin, Human
Research Papers that Mention the Interaction
“With increasing amounts of HS , the fractional uptake of T3 and T4 diminished and the C/M gradient for T4 was less than 1.”
Metabolism of L-thyroxine (T4) and L-triiodothyronine (T3) by human fibroblasts in tissue culture: evidence for cellular binding proteins and conversion of T4 to T3.“The twofold greater amount of T4 bound to the mutant HSA in the homozygote, relative to heterozygotes, is an adaptive requirement to maintain a normal free T4 concentration.”
“The circular dichroism spectra of thyroxine bound to R218H and R218P HSA were markedly different, indicating that the structure of the thyroxine/HSA complex is different for either protein.”
“These results suggest that the glycosylation of HSA causes a variation in the electrostatic interaction between T4 and HSA.”
“ L-thyroxine has been reported to bind to four sites (Tr) in HSA ; Tr1 and Tr4 are placed in the N-terminal and C-terminal part of the protein, respectively.”
Mutants and molecular dockings reveal that the primary L-thyroxine binding site in human serum albumin is not the one which can cause familial dysalbuminemic hyperthyroxinemia.
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