“Based on these observations, the chapter explains that TRH stimulates the hydrolysis of PtdIns(4,5)P 2 to InsP 3 that, in turn, mobilizes calcium from a nonmitochondrial pool leading to elevation of [Ca 2+ ] i then to activation of exocytosis and to stimulated prolactin secretion.”
“The chapter presents evidence from the studies in GH 3 cells—(… by mobilizing calcium from an intracellular, nonmitochondrial pool; (2) TRH … phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P 2 ), a minor plasma membrane phospholipid, to yield … is capable of rapidly mobilizing calcium from an intracellular, non mitochondrial pool.”