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Possible Interaction: Thyrotropin-Releasing Hormone and Phosphatidylinositol 4,5-Diphosphate

Research Papers that Mention the Interaction

Thyrotropin-releasing hormone stimulates the hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) in GH3 cell membranes.
The Journal of biological chemistry  •  1992  |  View Paper
In cells labeled by base exchange after permeabilization TRH stimulated a very small increase in 3H-labeled IPs of only 0.21 +/- 0.02% of 3H-labeled lipids in 20 min or only 7% of the 3H radioactivity in phosphatidylinositol 4,5-bisphosphate.
The Journal of biological chemistry  •  1990  |  View Paper
TRH increased inositol trisphosphate, inositol bisphosphate and inositol monophosphate, and decreased PIP2 and phosphatidylinositol 4-phosphate levels.
Molecular and Cellular Endocrinology  •  1987  |  View Paper
TRH caused rapid hydrolysis of labeled phosphatidylinositol 4,5-bisphosphate and a marked, prolonged increase in 45Ca2+ efflux from injected oocytes.
Molecular endocrinology  •  1987  |  View Paper
Thyrotropin releasing hormone (TRH) caused significant breakdown of phosphatidylinositol 4,5-bisphosphate (PIP2) in GH3 cells, but vasoactive intestinal peptide (VIP) did not.
Journal of biochemistry  •  1987  |  View Paper
TRH caused a rapid decrease in the level of PtdIns(4,5)P2 to 57% of control and stimulated an increase in inositoltriphosphate, the unique product of phospholipase C-mediated hydrolysis of PtdIns(4,5)P2, to a peak of 280% of control.
We demonstrate that TRH stimulates rapid hydrolysis of phosphatidylinositol 4,5-bisphosphate [PtdIns(4,5)P2] by a phospholipase C and elevates [Ca2+]i.
Endocrinology  •  1986  |  View Paper
In contrast, TRH caused only a transient increase in 32P-labeling of PtdIns(4,5)P2 that lasted less than 2 min.
Proceedings of the National Academy of Sciences of the United States of America  •  1986  |  View Paper
Based on these observations, the chapter explains that TRH stimulates the hydrolysis of PtdIns(4,5)P 2 to InsP 3 that, in turn, mobilizes calcium from a nonmitochondrial pool leading to elevation of [Ca 2+ ] i then to activation of exocytosis and to stimulated prolactin secretion.
The chapter presents evidence from the studies in GH 3 cells—(… by mobilizing calcium from an intracellular, nonmitochondrial pool; (2) TRH … phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P 2 ), a minor plasma membrane phospholipid, to yield … is capable of rapidly mobilizing calcium from an intracellular, non mitochondrial pool.
Recent progress in hormone research  •  1985  |  View Paper
Thyrotropin-releasing hormone (TRH) stimulates hydrolysis of phosphatidylinositol 4,5-bisphosphate (PtdIns-4,5-P2) by a phospholipase C (or phosphodiesterase) and elevates cytoplasmic-free Ca2+ concentration ([Ca2+]i) in GH3 pituitary cells.
The Journal of biological chemistry  •  1984  |  View Paper
From the analysis of inositol phosphates in the presence of Li+ which inhibits their dephosphorylation, it can be concluded that the hydrolysis of phosphatidylinositol 4,5‐biphosphate , and possibly of phosphatidylinositol 4‐phosphate by phospholipase C is markedly accelerated by TRH.
FEBS letters  •  1984  |  View Paper
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