Possible Interaction: Thyrotropin-Releasing Hormone and Calcium Supplement

“ TRH stimulates a biphasic increase in intracellular free calcium ion , [Ca2+]i.”

“ TRH causes biphasic changes in the concentration of cytosolic free calcium [( Ca2+]i) in GH4C1 cells and biphasic changes in hormone secretion.”

“Data from animal studies employing thyrotropin- and prolactin-secreting cells that demonstrate that thyrotropin-releasing hormone elevates the concentration of calcium ion free in the cell cytoplasm are presented.”

“Even when Cai was elevated by K depolarization, it could still be further increased by TRH , suggesting that these two stimuli mobilize calcium from two different pools and by different mechanisms.”

“An addition of TRH caused an obvious increase in intracellular calcium concentration in chinese hamster ovary cells expressing this receptor.”

“When stimulated by thyrotropin releasing hormone (TRH) or elevated K+ concentrations, only the latter caused cell calcium levels to rise although both resulted in hormone release.”

“The L-type Ca2+ current is also inhibited by other agents that mobilize intracellular Ca2+, including thyrotropin releasing hormone (TRH) and ryanodine, but in a matter distinct from caffeine.”

“However, regulation of PPII activity by TRH was inhibited by a phospholipase C β inhibitor or chelation of intracellular calcium.”

“The latency of the response to TRH was significantly shorter in the presence of extracellular Ca , suggesting Ca entry preceded the response, i.e. major depletion of Ca stores.”

“The presence of nitrendipine, 2,5-di-(tert-butyl)-1,4-benzohydroquinone (tBHQ), or TRH during the re-exposure to external calcium blocked this recovery of subsequent responses to TRH in the presence of only 0.1 microM [Ca2+]e.”