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“Moreover, all-trans-retinoic acid increased the mRNA expression of thyroglobulin and decreased both the mRNA expression and secretion of interleukin-6 and leukemia inhibitory factor while significantly stimulating growth.”
Cancer biotherapy & radiopharmaceuticals • 2007 | View Paper
“Median Tg was increased from 105-840 microg/liter during RA therapy in the responder group, which was significantly higher than the nonresponder group (173-134 microg/liter).”
“Response to RA is associated with a significantly higher increase of Tg , suggesting that a restoration of Tg synthesis can be addressed as a redifferentiation parameter in these patients.”
Journal of nuclear medicine : official publication, Society of Nuclear Medicine • 1998 | View Paper
“In conclusion, RA inhibits the synthesis of TPO and Tg via the suppression of thyroid-specific gene expression although the exact site of RA action on these genes in human thyroids remains to be further elucidated.”
“Northern gel analysis using the specific cDNA probes showed that RA suppressed the accumulation of TPO and Tg mRNA stimulated by TSH in a time- and dose-responsive manner.”
“These results suggest that RA may play a regulatory role in Tg and TPO gene expression, subsequently resulting in the suppression of thyroid hormone synthesis.”