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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Thrombopoietin
supplement:
Tyrosine
Research Papers that Mention the Interaction
“We demonstrate that PMN express the TPO receptor c-Mpl and that TPO induces STAT1 tyrosine phosphorylation and the formation of a serum inducible element complex containing STAT1.”
Regulation of polymorphonuclear cell activation by thrombopoietin.“ Thrombopoietin also induced tyrosine phosphorylation of Vav in FDCP-2 cells, genetically engineered to express human c-Mpl (FDCP-hMpl5).”
“To investigate the signaling processes induced by thrombopoietin, we have employed human platelets and recently demonstrated that thrombopoietin induces rapid tyrosine phosphorylation of Jak-2, Tyk2, Shc, Stat3, Stat5, p120(c-cbl) and other proteins in human platelets.”
“Evaluation of protein tyrosine phosphorylation following exposure to ligand revealed that TPO stimulation induced an elevated level of tyrosine phosphorylation of the adaptor protein Shc when compared with IL-3.”
“ TPO stimulated cell proliferation and induced the expression of megakaryocyte lineage-specific AP-51 and CD61 cell surface antigens and tyrosine phosphorylation of the signaling proteins in transformants expressing full length human Mpl.”
“Recently, we and others have shown that thrombopoietin induces rapid tyrosine phosphorylation of Jak2 and other proteins in human platelets and BaF3 cells, genetically engineered to express c-Mpl, a receptor for thrombopoietin.”
“ Thrombopoietin also induced tyrosine phosphorylation of Stat3 and Stat5 in FDCP-2 cells genetically engineered to constitutively express human c-Mpl.”
“ Thrombopoietin induced tyrosine phosphorylation of Stat3 and Stat5 in these cells.”
“Following receptor engagement, ML induces tyrosine phosphorylation of a number of membrane associated kinases and adaptor molecules, including SHC, JAK2, PLC-gamma and the mpl receptor itself.(ABSTRACT TRUNCATED AT 250 WORDS)”
“Miyakawa, Y., Oda, A., Druker, B.J., Miyazaki, H., Handa, M., Ohashi, H. & Ikeda, Y. (1996) Thrombopoietin induces tyrosine phosphorylation of Stat3 and Stat5 in human blood platelets.”
“ TPO also induced tyrosine phosphorylation of PDGFRα but not PDGFRβ, and promoted the formation of PDGFRαβ heterodimer complexes.”
“Triggering of these cell lines by TPO transiently up-regulated tyrosine phosphorylation of JAK-2 and Shc, indicating that their receptor is functional.”
“ TPO induced tyrosine phosphorylation of the TPO receptor but not the erythropoietin (EPO) receptor.”
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