Possible Interaction: Thrombopoietin and Tretinoin

“On the other hand, 10‐12 M ATRA significantly promoted the growth of CFU‐meg, in the presence either of thrombopoietin or of IL‐3 + GM‐CSF, and induced a reproducible stimulation of the immature CD34+ DR− subset.”

“The stimulatory effect on megakaryocytopoiesis should be considered in the perspective of a potential use of low‐dose ATRA , combined with thrombopoietin or other cytokines, in pathological conditions where the megakaryocytic compartment is impaired and the stimulation of megakaryocytopoiesis is requested.”