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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Threonine
supplement:
Vitamin B 6
Research Papers that Mention the Interaction
“One possible explanation for the change in value of the activity ratio is that serine and threonine affect differently the binding of pyridoxal 5′-phosphate, thus altering differently the balance between the amount of active holoenzyme and inactive apoenzyme in the reaction systems.”
Influence of monovalent cations on the activity of L-serine (L-threonine) dehydratase from rat liver. The control of threonine-serine activity ratio.“However, at pH 7.2, the addition of pyridoxal phosphate leads to a tripling of the small activity toward l-threonine.”
“This observation constitutes the first direct evidence in support of the view that 4‐hydroxy‐l‐threonine is implicated in the biosynthesis of vitamin B6.”
Growth response to 4‐hydroxy‐l‐threonine of Escherichia coli mutants blocked in vitamin B6 biosynthesis“Incubation of dehydratase with L-threonine shifted the absorption maximum of the enzyme-bound pyridoxal phosphate from 413 to 425 nm; addition of glyoxylate completely prevented the threonine-mediated spectral shift.”
“l-Serine O-sulphate and l-threonine O-sulphate are degraded in the presence of pyridoxal 5'-phosphate to yield equimolar amounts of the corresponding keto acid, ammonia and sulphate.”
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