Possible Interaction: Threonine and Valine

“Among amino acids, glycine, lysine, and total amino acids were positively correlated with birth weight, whereas valine and threonine showed a negative correlation.”

“ Threonine was most effective in increasing the degree of parasitaemia but its effect was further enhanced when it was combined with dietary excess of certain other amino acids, notably valine , isoleucine and methionine.”

“Hydroxynorvaline DL-alpha-amino-beta-hydroxyvaleric acid ) was shown to competitively inhibit the activation of threonine and valine when tested with tRNA and synthetases prepared from whole chick embryos.”

“In fact, dual supplementation with Thr and Val showed synergy on the 2HB fraction of the polymer.”

“Our work shows the crucial role of the cis-Pro loop, as changing valine to threonine in this motif completely abolishes the protein function in vivo.”

“This analysis suggests that isoleucine is a negative effector, and valine is a very weak positive effector, but that at high concentrations valine inhibits activity by competing with threonine for binding to the active site.”

“Substitution of residue 42 with alanine and residue 58 with alanine or valine in the presence of threonine 195 results in trypsin variants that are 102–104‐fold less active than wild type in kcat/KM but >106‐fold more active than the Ser 195 → Thr single variant.”

“Two additional threonines are located near the canonical start of the kinase domain, and their individual mutation to valine strongly inhibits receptor phosphorylation and signaling activity.”

“ L-Valine at high concentration acts as a substrate analogue and competitively inhibits L-threonine binding at the active site; the K1 is 1.6 x 10(-2) M.”

“These results suggest that threonine inhibits B. subtilis by causing valine starvation.”