Possible Interaction: Threonine and Uridine Triacetate

“From these observations we estimate that the phosphorylation of Thr 231, Ser 235, and Ser 262 contributes approximately 26, approximately 9, and approximately 33%, respectively, of the overall inhibition of tau binding to microtubules.”

“Phosphorylation of Ser and Thr residues has the potential to impact the local and global structure of Tau.”

“In the entire study group, the increase in tau phosphorylated at threonine 181 (p-tau(181)) was associated with a decline in verbal episodic memory (β = -0.30, p = 0.01) and HipV reduction (β = -0.27, p = 0.02).”

“A significant increase in hyperphosphorylated tau proteins (P-tau) in CSF has been … of primary dementia disorders from AD.2 Recently, we have shown that tau … threonine 231 (P-tau231P) correlates with cognitive decline in subjects with mild cognitive … their accuracy to predict cognitive deterioration within subjects with MCI.”

“By contrast, treated animals had a significant reduction of tau phosphorylation at specific sites: Ser396; Ser396/Ser404; and Thr 231/Ser 235.”

“Recently, we demonstrated that this unique group of serines and threonines has a critical role in controlling tau toxicity in a Drosophila model of tauopathy.”