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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Threonine
drug:
Tacrolimus
Research Papers that Mention the Interaction
“In mouse aortas, incubation with tacrolimus increased protein kinase C activity and basal endothelial nitric oxide synthase phosphorylation at threonine 495 but reduced basal and agonist-induced endothelial nitric oxide synthase phosphorylation at serine 1177, a mechanism known to inhibit synthase activity.”
Tacrolimus reduces nitric oxide synthase function by binding to FKBP rather than by its calcineurin effect.
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