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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Thimerosal
supplement:
Calcium Supplement
Research Papers that Mention the Interaction
“Studies with permeabilized cells or organelles show that the effect of thimerosal on calcium is dependent on the concentration: low concentrations of thimerosal stimulate calcium release, high concentrations are inhibitory.”
“ Thimersal causes a release of calcium from intracellular stores in many cells types; this is followed by an influx of extracellular calcium.”
Thimerosal: a versatile sulfhydryl reagent, calcium mobilizer, and cell function-modulating agent.“ Thimerosal and EtHgCl also induced a calcium (Ca2+) influx with a peak at 3h, suggesting that Ca2+ influx is a secondary event following ROS induction as Ca2+ influx was suppressed after pretreatment with NAC but not with thiol-independent antioxidants.”
“ Thimerosal induced oscillations of intracellular calcium in a significantly higher proportion of metaphase II oocytes (10/11) compared with metaphase I oocytes (3/8; P < 0.2).”
“Application of 1 microM thimerosal after a 10 s prepulse of 10 microM evoked oscillations of intracellular calcium.”
“Incubation of neurons with TH also induced the rise in the intracellular calcium and zinc concentration and decrease in mitochondrial membrane potential, and these effects were abolished by all the sulfur containing compounds studied and administered at 600 μM concentration, except Met.”
Low molecular weight thiols reduce thimerosal neurotoxicity in vitro: modulation by proteins.“Stimulation of the plasma membrane Ca2+-channels with thimerosal showed a considerable reduction of the calcium entry in cell precursors of the both species.”
“ Thimerosal and methylmercury at concentrations ranging from 0.3 to 10 microM increased the intracellular concentration of Ca2+ ([Ca2+]i) in a concentration-dependent manner.”
“ Thimerosal mobilized sequestered calcium , and evoked modest store-dependent calcium entry.”
“Significant inhibition of phagocytosis is observed after exposure of hemocytes to 10 microM or higher concentrations of thimerosal , which is known to deplete intracellular calcium stores in mammalian cells.”
“ Thimerosal can have both sensitizing (at concentrations of <2 microM) and inhibitory (at concentrations of >2 microM) effects on InsP3-induced Ca2+ release (IICR) from cerebellar microsomes.”
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