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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Thimerosal
supplement:
Arachidonate
Research Papers that Mention the Interaction
“The dramatic increase in production of leukotrienes by neutrophils when a physiological stimulus such as GM-CSF/fMLP is employed in the presence of thimerosal suggests a critical regulatory role of arachidonate reacylation that limits leukotriene biosynthesis in concert with 5-lipoxygenase and cytosolic phospholipase A2α activation.”
Effect of Arachidonic Acid Reacylation on Leukotriene Biosynthesis in Human Neutrophils Stimulated with Granulocyte-macrophage Colony-stimulating Factor and Formyl-methionyl-leucyl-phenylalanine*“Moreover, the inhibition of the reacylation of the released arachidonate with thimerosal results in greater than 4-times as much arachidonate released.”
“These eicosanoids were also produced in kidney marrow cells stimulated with ATP, and this production was greatly enhanced by preincubation with thimerosal , an inhibitor of arachidonate reacylation into phospholipids.”
Lysophospholipid acyltransferases and eicosanoid biosynthesis in zebrafish myeloid cells.
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