Possible Interaction: Thiamine and Vitamin C

“In addition, emerging evidence suggests that the combination of vitamin C , corticosteroids and thiamine may act synergistically to reverse sepsis induced organ dysfunction.”

“As with acetaldehyde, pretreatment with high oral doses ofl-ascorbic acid ,l-cysteine, and a combination of these protectants in reduced amounts with thiamin gave a high degree of protection against lethal doses of acrolein.”

“As adverse effect, ascorbic acid may cause oxalate accumulation in the kidneys that can be prevented with the concomitant use of thiamine.”

“Although the positive results of the CITRIS-ALI study on mortality question the necessity of co-administration of hydrocortisone and thiamine when vitamin C is dosed sufficiently high, notably 66% of patients in CITRIS-ALI study received corticosteroids.”

“Combining intravenous vitamin C with corticosteroids and thiamine reduced mortality by 31.9% in a beforeand-after cohort.”

“… vitamin C (OR = 0.2, for the highest versus the lowest intake quintile; 95% CI: 0.2–0.4), β-carotene (… = 0.4; 95% CI: 0.2–0.5), folic acid (OR = 0.4; 95% CI: 0.2–0.6), thiamin (OR = 0.4; 95% …: 0.4–0.9).”

“In conclusion, ascorbic acid combined with thiamine exhibited protective effect on reproductive system by inhibiting Pb-induced excessive cell apoptosis.”

“However, simultaneous supplementation of ascorbic acid and thiamine at the highest dose promoted testicular cell apoptosis via increased expressions of TGFbeta1 and caspase-3.”

“We explored the mechanism and examine the impacts of combined administration of ascorbic acid and thiamine at different levels on apoptosis in the testes of lead-exposed mice.”

“ Ascorbic acid at 0.02--0.1 mM increased the thiamine diphosphatase activity by 20--600% and produced a significant amount of lipid peroxide, which was measured with thiobarbiturate under the same conditions as the enzyme.”

“Observations on the synergistic action of thiamine and ascorbic acid were made as far back as 1939 when Kasahara and his co-workers injected ascorbic acid and thiamine subcutaneously into young rats and obtained a growth enhancement.”

“On the other hand, at least thiamine , pantothenic acid, and riboflavin were believed to stimulate independently the synthesis of ascorbic acid in some tissues.”