Possible Interaction: Thiamine and Vitamin B 6

“Conversely, half of the pyridoxine responders worsened when given large doses of thiamin.”

“Two chronic alcoholic patients developed severe encephalopathy while receiving high doses of parenteral thiamine and pyridoxine.”

“Abstract It has been shown that pyridoxine inhibits thiamine biosynthesis.”

“Inactivation of E1 by the pyridoxal phosphate-cyanide treatment was prevented by thiamin pyrophosphate.”

“In S. uvarum … synthesis of vitamin B6 was maximally inhibited … addition of thiamin (1.5 nmol ml-1) to the growth medium without affecting cell growth, whereas the amounts of cellular … increased in the presence of the thiamin antagonist, pyrithiamin or oxythiamin, at concentrations that did not affect growth.”

“In contrast, the vitamin B6 content of all the yeasts tested, except Pichia membranaefaciens IFO 0189, decreased markedly in the presence of thiamin.”

“It has been reported that all of the effects of thiamine are abolished by adding pyridoxine to the medium.”

“Concomitant addition of pyridoxine with thiamine to the growth medium prevented the growth inhibition and eliminated these phenomena caused by thiamine.”

“Furthermore, immediate restoration of respiratory activity was observed upon the addition of pyridoxine in the course of cultivation with thiamine.”

“Addition of pyridoxine to the medium prevented completely this effect of thiamine as observed in the case of respiratory activity.”

“Addition of pyridoxine to the medium prevented the growth inhibition and eliminated these effects of thiamine.”

“ Pyridoxal was shown to inhibit the conversion of thiamine monophosphate to thiamine by a cell-free enzyme system prepared from baker's yeast.”

“Summary The biosynthesis of thiamine from 2-methyl-4-amino-5-hydroxymethylpyrimidine and 4-methyl-5-(hydroxyethyl) thiazole, or from their pyro-and monophosphate esters respectively, was inhibited by pyridoxal.”