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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Thiamine
supplement:
Vitamin B 12
Research Papers that Mention the Interaction
“ Vitamin B12 may contribute to this effect, whereas vitamin B1 alone exhibited only a slight effect on nociception.”
Acute effects of vitamin B6 and fixed combinations of vitamin B1, B6, B12 on nociceptive activity evoked in the rat thalamus: Dose-response relationship and combinations with morphine and paracetamol“The degradation losses of cyanocobalamin in the presence of increasing concentrations of thiamin and niacin ranged between 6%-13% and added sorbitol significantly prevented the loss of cyanocobalamin (p<0.05).”
Sorbitol enhances the physicochemical stability of B12 vitamers.“It was confirmed that the hydrolytic products of thiamine affect the stability of cyanocobalamin , and that low concentrations of ferric ions can protect cyanocobalamin against the effects of thiamine breakdown products, but this occurs without appreciably affecting the stability of thiamine itself.”
“There are several previously reported observations which suggest that this rate might be much slower for cyanocobalamin than for some of the other watersoluble vitamins, such as thiamine , nicotinic acid (niacin), and ascorbic acid.”
“ Vitamin B12 has been found to deteriorate progressively in association with aneurine and nicotinamide in solution over a pH range of 4 to 4·5.”
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