Possible Interaction: Thiamine and Thiamine Pyrophosphate

“All subjects randomly assigned to receive thiamine showed increases in TPP concentrations compared with control subjects.”

“This enzymatic activity, located in the mid-piece fraction of spermatozoa, was enhanced by thiamine pyrophosphate and Mg2+ and inhibited by thiamine thiazolone pyrophosphate.”

“Conclusions: Plasma thiamine and TMP correlated positively with eThDP , and all thiamine forms responded significantly to thiamine intervention.”

“ Parenteral thiamine administration markedly increases TDP levels.”

“We consider that the exogenous administration of TPP facilitates the utilization of this molecule, regulating some metabolic processes such as phosphorylation of thiamine by TPPK, energy consumption (ATP), as well as mitochondrial activity, inducing eventually NO synthesis.”

“ Thiamine regulates the expression of some genes that code for enzymes using thiamine diphosphate as cofactor.”

“In the cross-sectional study group, thiamin intake was below the recommended in only 19.2 per cent subjects and thiamin intake/100 kcal/day revealed a significant negative correlation with TPP effect.”

“Dietary intakes of thiamine showed a significant inverse relationship with TPP effect.”

“Conversion of thiamine to TPP significantly decreased in the CIS group.”

“The inhibition of thiamine uptake by thiamine pyrophosphate and the efflux of endogenous thiamine pyrophosphate, caused by externally added thiamine, suggest the existence of a thiamine pyrophosphate/thiamine antiporter which could play an active role in the turnover of intramitochondrial thiamine pyrophosphate linked enzymes.”