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Discover Supplement-Drug Interactions

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Last Updated: 5 months ago

Possible Interaction: Thiamine Pyrophosphate and Benfotiamine

Research Papers that Mention the Interaction

After benfotiamine administration, the peak plasma concentration of TDP exceeded that in healthy subjects by 51%.
Conclusion: Compared with thiamine nitrate, the oral administration of benfotiamine leads to higher TDP concentrations in erythrocytes accompanied with a significant improvement of the erythrocyte transketolase activity in ESRD patients.
European Journal of Clinical Pharmacology  •  2000  |  View Paper
HPLC analysis revealed that sulbutiamine and benfotiamine significantly increased intracellular thiamine and TPP concentrations in vitro, corresponding with reduced levels of PDH phosphorylation.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie  •  2020  |  View Paper
BFT facilitates the action of thiamine diphosphate , a cofactor for the enzyme transketolase.
European review for medical and pharmacological sciences  •  2018  |  View Paper
Benfotiamine (S-benzoylthiamine O-monophosphate), an amphiphilic S-acyl thiamine derivative, prevents the progression of diabetic complications, probably by increasing tissue levels of thiamine diphosphate and so enhancing transketolase activity.
BMC pharmacology  •  2008  |  View Paper