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Discover Supplement-Drug Interactions
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Last Updated: 5 years ago
supplement:
Thiamine Pyrophosphate
drug:
Benfotiamine
Research Papers that Mention the Interaction
“TM and TDP exhibited moderate accumulation on repeated administration of benfotiamine.”
Safety, Tolerability and Pharmacokinetics of Single and Multiple Ascending Doses of Benfotiamine in Healthy Subjects“HPLC analysis revealed that sulbutiamine and benfotiamine significantly increased intracellular thiamine and TPP concentrations in vitro, corresponding with reduced levels of PDH phosphorylation.”
“ BFT facilitates the action of thiamine diphosphate , a cofactor for the enzyme transketolase.”
“ Benfotiamine (S-benzoylthiamine O-monophosphate), an amphiphilic S-acyl thiamine derivative, prevents the progression of diabetic complications, probably by increasing tissue levels of thiamine diphosphate and so enhancing transketolase activity.”
Benfotiamine, a synthetic S-acyl thiamine derivative, has different mechanisms of action and a different pharmacological profile than lipid-soluble thiamine disulfide derivatives
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