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Discover Supplement-Drug Interactions

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Last Updated: 5 days ago

Possible Interaction: Thiamine and Benfotiamine



Research Papers that Mention the Interaction

TM and TDP exhibited moderate accumulation on repeated administration of benfotiamine.
Drug design, development and therapy  •  2021  |  View Paper
Benfotiamine , a more bioavailable thiamine analog, has been proposed as an alternative to counteract these changes related to thiamine metabolism.
The supplementation with 150 mg/kg of benfotiamine for 30 days increased the concentrations of thiamine diphosphate in the hippocampus and entorhinal cortex.
Experimental Gerontology  •  2020  |  View Paper
HPLC analysis revealed that sulbutiamine and benfotiamine significantly increased intracellular thiamine and TPP concentrations in vitro, corresponding with reduced levels of PDH phosphorylation.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie  •  2020  |  View Paper
It is quite clear that benfotiamine is absorbed much more … than water-soluble thiamine salts: maximum plasma levels of thiamine are about 5 … higher after benfotiamine , the bioavailability is at maximum about 3.6 times as high as that of thiamine hydrochloride and better than other lipophilic thiamine derivates.
International journal of clinical pharmacology and therapeutics  •  1996  |  View Paper
The absorption rate and extent of benfotiamine systemic availability of thiamine were significantly increased indicating higher bioavailability of thiamine from oral dose of benfotiamine compared to oral dose of thiamine hydrochloride.
Journal of clinical pharmacology  •  2014  |  View Paper
Oral administration of benfotiamine raises thiamine levels in blood and tissues to a much higher degree than the water-soluble salts.
Alternative medicine review : a journal of clinical therapeutic  •  2006  |  View Paper
The administration of thiamine or benfotiamine (200 mg/kg/day) in drinking water decreased aggressive behavior following 3-weeks of ultrasound exposure and benfotiamine , reduced floating behavior in the swim test.
Neuropharmacology  •  2019  |  View Paper
Coincident, thiamine and benfotiamine improved learning and extinction of contextual fear, and the acquisition of the step‐down avoidance task.
Progress in Neuro-Psychopharmacology and Biological Psychiatry  •  2017  |  View Paper
In erythrocytes, thiamine levels were 4- and 25-fold higher in the groups treated with thiamine and benfotiamine , respectively, compared with the untreated groups.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences  •  2013  |  View Paper
ConclusionOur results show that, though benfotiamine strongly increases thiamine levels in blood and liver, it has no significant effect in the brain.
BMC pharmacology  •  2008  |  View Paper
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