Possible Interaction: Thiamine and Benfotiamine

“ TM and TDP exhibited moderate accumulation on repeated administration of benfotiamine.”

“ Benfotiamine , a more bioavailable thiamine analog, has been proposed as an alternative to counteract these changes related to thiamine metabolism.”

“The supplementation with 150 mg/kg of benfotiamine for 30 days increased the concentrations of thiamine diphosphate in the hippocampus and entorhinal cortex.”

“HPLC analysis revealed that sulbutiamine and benfotiamine significantly increased intracellular thiamine and TPP concentrations in vitro, corresponding with reduced levels of PDH phosphorylation.”

“It is quite clear that benfotiamine is absorbed much more … than water-soluble thiamine salts: maximum plasma levels of thiamine are about 5 … higher after benfotiamine , the bioavailability is at maximum about 3.6 times as high as that of thiamine hydrochloride and better than other lipophilic thiamine derivates.”

“The absorption rate and extent of benfotiamine systemic availability of thiamine were significantly increased indicating higher bioavailability of thiamine from oral dose of benfotiamine compared to oral dose of thiamine hydrochloride.”

“Oral administration of benfotiamine raises thiamine levels in blood and tissues to a much higher degree than the water-soluble salts.”

“The administration of thiamine or benfotiamine (200 mg/kg/day) in drinking water decreased aggressive behavior following 3-weeks of ultrasound exposure and benfotiamine , reduced floating behavior in the swim test.”

“Coincident, thiamine and benfotiamine improved learning and extinction of contextual fear, and the acquisition of the step‐down avoidance task.”

“In erythrocytes, thiamine levels were 4- and 25-fold higher in the groups treated with thiamine and benfotiamine , respectively, compared with the untreated groups.”

“ConclusionOur results show that, though benfotiamine strongly increases thiamine levels in blood and liver, it has no significant effect in the brain.”