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Discover Supplement-Drug Interactions

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Last Updated: 2 years ago

Possible Interaction: Thiamine and Alpha-Ketoglutaric Acid

supplement:

Thiamine

Research Papers that Mention the Interaction

In mitochondria from spontaneous mammary carcinoma which have a thiamine diphosphate level comparable with that of muscle mitochondria from newborn rats, addition of thiamine diphosphate causes a small but distinct rise in the oxidation rate of pyruvate and α-ketoglutarate.
Experimental cell research  •  1962  |  View Paper
KGA is no longer oxidized in the TCA cycle, because thiamine limitation inhibits α-ketoglutarate dehydrogenase.
Applied Microbiology and Biotechnology  •  2016  |  View Paper