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Discover Supplement-Drug Interactions

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Last Updated: 6 months ago

Possible Interaction: Thiamine and Alpha-Ketoglutarate

supplement:

Thiamine

Research Papers that Mention the Interaction

A deficiency or malutilization of thiamin alters decarboxylation of pyruvate and alpha-ketoglutarate ; decreases transketolase formation; and reduces conversion of tryptophan to nicotinic acid and nicotinamide.
Annals of the New York Academy of Sciences  •  1982  |  View Paper
Taken together, the data suggest that thiamine decreases catabolism of amino acids by means of a complex and long-term regulation of metabolic flux through the tricarboxylic acid cycle, which includes coupled changes in activities of the ThDP-dependent dehydrogenases of 2-oxoglutarate and 2-oxoadipate and adjacent enzymes.
Biochemistry (Moscow)  •  2017  |  View Paper