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Discover Supplement-Drug Interactions
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Last Updated: 2 years ago
supplement:
Thiamine
supplement:
Alpha-Ketoglutarate
Research Papers that Mention the Interaction
“A deficiency or malutilization of thiamin alters decarboxylation of pyruvate and alpha-ketoglutarate ; decreases transketolase formation; and reduces conversion of tryptophan to nicotinic acid and nicotinamide.”
THIAMIN DEFICIENCY AND ALCOHOLISM“Taken together, the data suggest that thiamine decreases catabolism of amino acids by means of a complex and long-term regulation of metabolic flux through the tricarboxylic acid cycle, which includes coupled changes in activities of the ThDP-dependent dehydrogenases of 2-oxoglutarate and 2-oxoadipate and adjacent enzymes.”
Thiamine induces long-term changes in amino acid profiles and activities of 2-oxoglutarate and 2-oxoadipate dehydrogenases in rat brain
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