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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Theophylline
supplement:
Tubocurarine
Research Papers that Mention the Interaction
“Papaverine, theophylline and ephedrine elevated the LD50 values of d-tubocurarine by 12 to 26%.”
Decreased toxicity of d-tubocurarine after pretreatment with drugs elevating the intracellular level of c-AMP in mice“The adenosine receptor antagonists at the frog neuromuscular junction, 8‐PT and theophylline , increased in a concentration‐dependent manner the amplitude of e.p.p.s in the presence of tubocurarine.”
“From these findings, it is concluded that some drugs like theophylline or isoproterenol may diminish the side effects of d-tubocurarine and perhaps some other muscle relaxants.”
“Histamine release from rat mast cells due to d-tubocurarine was clearly depressed by pretreatment of theophylline or isoproterenol.”
“Reversal of a (+)-tubocurarine blocked muscle and antagonism of MEPP's depressed by (+)-tubocurarine, further indicate the postsynaptic action of theophylline.”
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