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Last Updated: 3 years ago

Possible Interaction: Theophylline and Andrographolide

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drug:

Theophylline

supplement:

Andrographolide

Research Papers that Mention the Interaction

“As andrographolide inhibits the CYP1A2 activity in vitro, it potentially interacts with theophyllines that are mainly metabolized by CYP1A2.”

Effects of andrographolide on the pharmacokinetics of aminophylline and doxofylline in rats.

Drug research • 2013 | View Paper

“The results indicated that the clearance of theophylline was significantly increased and the area under concentration-time curve (AUC) was reduced in both AG and APE pretreated groups at low-dose theophylline administration (1mg/kg).”

Herb-drug interaction of Andrographis paniculata extract and andrographolide on the pharmacokinetics of theophylline in rats.

Chemico-biological interactions • 2010 | View Paper

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