Possible Interaction: Theophylline and Alpha-Ketoglutaric Acid

“Summary Theophylline , at a concentration from 1.0–10.0 mM, significantly inhibited glucose production from glycerol, malate, pyruvate, and α-ketoglutarate by the isolated tubules of rat renal cortex; the higher the theophylline concentration in the incubation media the smaller the glucose production rates were.”

“The efficiency of oxidative phosphorylation was significantly increased in the theophylline fed rats when succinate or α-ketoglutarate was used as the substrate.”