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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Theophylline
supplement:
Adrenocorticotropic Hormone
Research Papers that Mention the Interaction
“In 10 healthy male volunteers, the short‐term administration of theophylline , which affects both intracellular calcium and cAMP, lowered basal cortisol levels but augmented the in vivo cortisol response to short‐term corticotropin stimulation.”
The effects of theophylline and nifedipine on corticotropin‐stimulated cortisol secretion“Further, theophylline depression of ACTH stimulated steroid output may be helpful in understanding the interplay between a number of factors in the control of adrenal steroid biosynthesis and release.”
“Growth hormone and ACTH stimulated lipolysis at high concentrations, in the presence of theophylline.”
Acute effects of metabolic hormones in swine.“The maximal lipolytic activity (MAX) obtained with ACTH plus Theo was minimal in the newborn, greatly increased in young animals, and reduced during the growing period; however, the sensitivity did not change.”
“ Theophylline , a phosphodiesterase inhibitor, stimulated lipolysis and greatly enhanced the activity of adrenocorticotropin.”
“When phosphodiesterase activity was elevated and cyclic AMP content maintained at a high level by incubation of cells with ACTH plus theophylline , insulin produced a further increase in enzyme activity.”
“ Theophylline mimicked the stimulatory effect of adrenocorticotropic hormone and dibutyryl cyclic AMP and increased the uptake of 45 Ca 2+ by rat adrenal glands in vitro .”
“The first alternative is favored since the phosphodiesterase inhibitor theophylline , used at 10 mM concentration, stimulated steroid production less effectively than calcium in the presence of ACTH , but more effectively than calcium in the absence of ACTH.”
“ Theophylline inhibited the glycolytic action of ACTH , dibutyryl cyclic AMP and exogenous steroids, denoting that its effects are not confined to the inhibition of phosphodiesterase. (”
“Potentiation of adrenocorticotrophin stimulated adenosine 3′,5′-monophosphate levels was also observed in the presence of theophylline (0.5 and 1.0mM).”
“ Theophylline (1mM) was found to potentiate the steroidogenic effect of submaximal concentrations of adrenocorticotrophin.”
“ Theophylline (2mm) potentiated the effect of ACTH on protein kinase activity.”
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