Possible Interaction: Theanine and Doxorubicin Hydrochloride

“ Theanine increased the effects of the doxorubicin (DOX) as an antitumor agent in some tumors and enhanced the DOX level in tumor cells.”

“Moreover, theanine inhibited GSH reduction induced by DOX in the liver and heart.”

“We previously showed that theanine , a specific glutamate derivative in green tea, decreased doxorubicin (DOX)-induced adverse reactions such as the induction of the lipid peroxide level and the reduction of glutathione peroxidase activity in normal tissues.”

“Furthermore, the oral administration of theanine or green tea similarly enhanced the antitumor activity of DOX.”

“In M5076 ovarian sarcoma-bearing mice, theanine significantly enhanced the inhibitory effect of DOX on tumor growth and increased the DOX concentration in the tumor, compared to DOX-alone group.”

“Moreover, the combination of theanine with DOX suppressed the hepatic metastasis of ovarian sarcoma.”

“Namely, theanine increases the concentration of DOX in a tumor in vivo through inhibition of the glutamate transporter via the GS-X pump.”

“On the other hand, in vitro experiments proved that theanine inhibited the efflux of DOX from tumor cells, supporting a theanine-induced increase in the DOX concentration in tumors in vivo.”

“ Theanine , a major amino acid existing in green tea, enhanced the antitumor activity of doxorubicin (DOX) due to inhibition of DOX efflux from tumor cells.”

“These results suggested that the inhibition of DOX efflux was induced by the inhibition of glutamate transport by theanine.”

“We revealed the novel mechanism of enhancement of the antitumor efficacy of DOX via the inhibition of glutamate transporters by theanine.”

“Decreases in the creatinine clearance by DOX administration were attenuated by concurrent treatment with theanine , which was consistent with the change in histological renal images assessed by microscopic examination.”

“Reduced glutathione content, but not superoxide dismutase activity, was decreased following DOX administration, whereas this change was suppressed when theanine was given in combination with DOX.”

“The production of lipid peroxide in the kidney after DOX administration was suppressed by concurrent treatment with theanine.”

“The formation of cleaved caspase-3 protein in the group given DOX with theanine was significantly lower than that in the group treated with DOX alone.”

“These results suggest that theanine can protect against acute hepatic damage induced by DOX , which is attributed to the suppression of intrinsic caspase-3-dependent apoptotic signaling.”

“ Theanine increases the antitumor effect of doxorubicin (DOX) with decreasing adverse reaction.”

“We clarified the mechanism by which theanine decreases the adverse reaction of DOX on any metabolizing enzymes of theanine.”

“We previously showed that theanine , is a major amino acid in green tea, enhanced doxorubicin (DOX) induced antitumor activity.”

“Therefore theanine enhances the antitumor activity not only of DOX but also of cisplatin or CPT-11.”

“We have confirmed that theanine enhances the antitumor activity of DOX due to inhibition of DOX efflux from tumor cells.”