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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Thalidomide
supplement:
Tretinoin
Research Papers that Mention the Interaction
“HOXB7 was not upregulated but microarray analysis validated by real-time PCR identified four potential resistance genes (IL-8, HILDPA, IGFBPA, and ANGPTL4) whose upregulation by RA was suppressed by THAL.”
“However, RA may also induce the expression of resistance genes such as HOXB7 which can be suppressed by Thalidomide (THAL).”
“In conclusion, combined treatment with RA + THAL delayed growth of GBM xenografts and suppressed putative resistance genes associated with hypoxia and angiogenesis.”
“The synergistic effect of RA and THAL was corroborated by the effect on proliferation of glioblastoma cell lines in vitro.”
Inhibition of 13-cis retinoic acid-induced gene expression of reactive-resistance genes by thalidomide in glioblastoma tumours in vivo“The purpose was to test if thalidomide can inhibit 13‐cis RA‐induced HOXB7 expression and whether thalidomide may enhance the antiproliferative effect of 13‐cis RA in U343MG glioblastoma cells.”
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