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Discover Supplement-Drug Interactions
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Last Updated: 5 years ago
drug:
Tetrodotoxin
supplement:
Glutamate
Research Papers that Mention the Interaction
“ TTX significantly (p < 0.05) decreased resting Glu by 20%, whereas THA significantly (p < 0.05) increased resting Glu by 60%.”
Second-by-Second Measures of l-Glutamate in the Prefrontal Cortex and Striatum of Freely Moving Mice“The inhibitor of spike firing, tetrodotoxin (TTX) and the suppressor of Ca2+ entry, nitrendipine, both decreased the extent of loss, when delivered prior to Glu.”
“Perfusion of tetrodotoxin before application of either GLU or ASP blocked the excitatory effect of these amino acids on dopamine overflow.”
“The fast application of … 1 mM step of L-glutamate for 50–100 msec … the presence of TTX and dizolcipine (MK-801) onto patches excised from these neurons produced large glutamate-activated currents (GACs) … decayed with a single or double exponential time course despite the continued presence of agonist.”
“In the cortex and cerebellum the excitatory action of L-Glu on the release of [3H]AD was attenuated by tetrodotoxin (TTX).”
“Entry of (22)Na(+) also is accelerated by l-glutamate and this acceleration is inhibited by low concentrations of tetrodotoxin.”
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