“Moreover, THC increases the affinity of heme for HSA.”
“Possibly, the HSA conformational transition(s) induced by THC binding could account for drug delivery to the liver through receptor‐ mediated endocytosis.”
“ THC binds to two different binding sites of HSA (Kd1 ≤ 10−7 M and Kd2= 10−3 M) without affecting diazepam binding (Kd = 1.2 × 10−5 M).”