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Discover Supplement-Drug Interactions
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Last Updated: 2 years ago
supplement:
Adrenocorticotropic Hormone
Research Papers that Mention the Interaction
“These results demonstrate (1) that acute treatment with THC stimulates the secretion of ACTH as well as of CS; and (2) that extrahypothalamic sites and/or neural pathways mediate this effect.”
Corticotrophin and corticosterone secretion following Δ1-tetrahydrocannabinol, in intact and in hypothalamic deafferentated male rats“administration of delta(9)-THC (25, 50, 100 microg/rat) markedly increased plasma adrenocorticotropin hormone (ACTH) and corticosterone concentrations.”
“Intracerebroventricular injection of anandamide or THC (50 or 150 micrograms/rat) increased significantly the serum levels of ACTH and corticosterone in a dose-dependent manner and caused a pronounced depletion of CRF-41 in the median eminence.”
“It can be concluded with reasonable confidence that THC alters the secretion of the pituitary reproductive hormones, and that of ACTH as well, through actions in the brain.”
“ ACTH , cholera toxin, cyclic AMP but not pregnenolone-induced steroidogenesis in Y-1 functional mouse adrenal tumor cells was significantly inhibited by delta-9-tetrahydrocannabinol , cannabidiol, and cannabinol.”
Inhibition of cortiocosteroidogenesis by delta-9-tetrahydrocannabinol.
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