Possible Interaction: Tetraethylammonium and Calcium Supplement

“When increasing calcium entry with tetraethylammonium in 1.5 mM external calcium concentration, we find that synaptic output saturates at 0.22 vesicle per site, not at 1 vesicle per site.”

“In the presence of elevated potassium, 4-aminopyridine or tetraethylammonium , the secretagogue efficacy of calcium (but not barium) was markedly increased.”

“IK Ca was blocked by tetraethylammonium and charybdotoxin.”

“Although nifedipine (L-type calcium channel blocker) and tetraethylammonium reduced some calcium and calcium-dependent potassium currents, they had only a slight effect on the NO and histamine responses.”

“IK(Ca) was recorded at potentials more positive than −40 mV in Ca2+-containing bath solution, and was blocked by Ca2+ channel antagonists and tetraethylammonium ion (TEA+).”

“Interestingly, additional blockade of Ca2+‐activated K+ channels by tetraethylammonium abolished the improved relaxation to ACh in SHR on high calcium and on high potassium, but distinct responses were still observed in WKY rats and SHR on the combined supplement.”

“Extracellular K+ (10 mM) or K channel block with tetraethylammonium stimulated Ca pulsing.”

“The late 5-HT sensitive phase of the AHP was increased in amplitude when calcium entry was enhanced during the prolongation of action potentials caused by tetraethylammonium (TEA).”

“The overflow of [3H]norepinephrine was near normal when the calcium concentration of the perfusion medium was reduced from a control value of 2.5 to 0.25 mM in the presence of 20 mM tetraethylammonium.”

“The facilitatory effect of 30 mM tetraethylammonium gradually decreased with reduction in [ Ca 2 + ] concentration.”