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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Tetracycline
supplement:
Vitamin C
Research Papers that Mention the Interaction
“Both Vit C and NAC significantly attenuated the toxic effects of tetracycline to the antioxidant and testicular marker enzymes as well as markers of oxidative stress.”
“While Vit C and NAC significantly mitigated the toxic effect of tetracycline on sperm parameters, the antioxidants did not improve the adverse histopathologic changes induced by antibiotic.”
Tetracycline-induced reproductive toxicity in male rats: effects of vitamin C and N-acetylcysteine.“When the cells, before or after the TC treatment, were grown in presence of L-ascorbic acid (10 or 20 microgram/ml) for 48 h, there was significant decrease in the frequency of mutation induced by TC.”
“Inhibitors of protein synthesis, actinomycin D, tetracycline and cycloheximide, have a different effect on the increase in the monoaminooxidase activity evoked by introduction of ascorbic acid : tetracycline blocks the increase in the enzyme activity, actinomycin D has no effect on it.”
“ Ascorbic acid increased the rate of dialysis and the percentage of ultrafiltration of tritiated tetracycline from plasma.”
“The protective effect of ascorbic acid , isoascorbic acid and mannitol (the latter in dogs) against the nephrotoxicity of tetracycline is postulated to be secondary to an osmotic diuretic effect.”
“When injection of ascorbic acid into rats preceded that of tetracycline by 5 to 10 minutes, protection was marked; reversal of the order of injections with the same interval resulted in less protection.”
“administration of pure tetracycline · HCl at 50 mg/kg was prevented by concomitant administration of ascorbic acid at 125 mg/kg or higher.”
“Out of 13 chemotherapeutical agents tested, ofloxacine, N-succinimidylofloxacine, fleroxacine, tetracycline , 6-thiatetracycline, and doxycycline reacted with ascorbic acid with the development of the superoxide radical (O2.-).”
“The kinetics of the process of the survival of cells within 24 hours demonstrated that a combination of ofloxacine as well as tetracycline with ascorbic acid produced a statistically significant increase in log10 of CFU/ml in S. aureus as well as E. coli.”
[The effect of ascorbic acid on the antibacterial activity of selected antibiotics and synthetic chemotherapeutic agents in in vitro conditions].
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