Possible Interaction: Tetracycline and Ferric Ion

“This interaction leads to TC + Fe(III) coordinating complex formation.”

“Similarly, the tetracycline antibiotics in the presence of a ferric salt greatly stimulated the peroxidation of liposomal membranes.”

“To … tetracycline … ferric iron and the enhancement of infection by ferric iron by tetracycline, the actions of intraperitoneal antibiotic and local ferric ammonium citrate, given separately and …-pigs bearing lesions due to staphylococci, streptococci, a Proteus sp., an Erysipelothrix sp., Clostridium perfringens, Pseudomonas aeruginosa, Aeromonas hydrophila and Klebsiella pneumoniae.”

“These findings indicate the mutually influenced environmental transformation of TCs and Fe(II) and Fe(III) induced by their complexation.”

“Compared to without metals, Fe(III) enhanced the degradation rate of TTC , OTC and CTC by up to 20.67, 7.07 and 2.30 times, respectively, in clean water matrix, and also promoted degradation of TCs in real surface water and wastewater matrices.”

“The presence of Fe(III) ions was found to induce degradation of three tetracycline antibiotics (TCs), tetracycline (TTC), oxytetracycline (OTC) and chlorotetracycline (CTC), in aqueous solutions without light.”

“The presence of Fe(III) promoted the degradation of TCs in most experimental pH (5.0, 7.0 and 9.0) except at pH 9.0 for CTC.”

“Growth and Fe(III) reduction were inhibited by chloramphenicol, streptomycin, tetracycline , penicillin, ampicillin and 2 % NaCl (w/v).”

“Precise measurement with Fe+++ and tetracycline revealed that the molar ratio for neutralization increased with increasing concentrations of tetracycline ; from 1 to 625 mg/l the ratio increased over three-fold from 35 to 118.”