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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Tetracaine
supplement:
Phosphatidylethanolamine
Research Papers that Mention the Interaction
“l-1) of tetracaine , followed by removal of the perturbing agent by washing, produces a selective loss of the asymmetric orientation of phosphatidylethanolamine to the inner membrane layer, as evaluated by the accessibility of the lipid towards cleavage by phospholipase A2.”
Bacterial cytotoxins, amphotericin B and local anesthetics enhance transbilayer mobility of phospholipids in erythrocyte membranes. Consequences for phospholipid asymmetry.“Continued addition of TTC resulted in the eventual disappearance of the free PE signal and the corresponding growth of the signal from PE in contact with TTC.”
“ Tetracaine was observed to disorder the hydrocarbon region of the bilayer and to induce a conformational change in the PE headgroup.”
“This indicates that at low pH, when TTC is primarily charged, it has a much slower rate of lateral diffusion in the PE bilayer.”
The influence of local anesthetics on molecular organization in phosphatidylethanolamine membranes.
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