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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Tetracaine
supplement:
Calcium Supplement
Research Papers that Mention the Interaction
“The Ca2+ -induced Ca2+ release blocker tetracaine inhibited the rise in [Ca2+]i induced by both caffeine and ATP, with apparent inhibitory constants of 70 μM and 100 μM, respectively.”
Mechanism of the ATP-induced rise in cytosolic Ca2+ in freshly isolated smooth muscle cells from human saphenous vein“In the presence of tetracaine the release of intracellular Ca is lower to some extent, but then it surpasses the control level.”
“Tetracaine, a cation at neutral pH, was also found to be an … SO42− exchange with an apparent K1 of 0.8 mM. Although tetracaine was observed … displace calcium from non-specific sites on the erythrocyte membrane, it showed no … on the apparent inhibition constant of Ca2+ for SO42− exchange.”
“The addition of calcium was found to reverse the quenching of 12-(9-anthroyl)stearic acid by tetracaine in the presence of red cell membranes.”
“It … and tetracaine not only affect key steps of the Ca-ATPase … exert an indirect effect on membrane permeability to calcium and suggest that the consequent myoplasmic calcium increase induced by the anesthetics might account …, such as sustained contraction and eventual rigidity of both fast-twitch and masticatory muscles.”
Differential mechanism of the effects of ester-type local anesthetics on sarcoplasmic reticulum Ca-ATPase“A high calcium concentration stiffens pure lipid membranes and strongly reduces the effect of tetracaine.”
“In voltage clamped frog skeletal muscle fibres 0.2 mM tetracaine strongly suppresses Ca2+ release.”
“Experiments with isolated SR vesicles showed that 1mm tetracaine inhibited CICR , over a wide range of pCa but 3–5mm tetracaine induced rapid Ca2+ release.”
“Lower concentrations of tetracaine (0.5mm) and procaine (⩽10mm) blocked contractions due to caffeine (at pCa ⩾6.73), sulphydryl oxidizing agents, or Ca2+-induced Ca2+ release (CICR).”
“Both inhibition of cADPR production by nicotinamide (Nicot) and blockade of Ca2+-induced Ca2+ release (CICR) by tetracaine ( TC ) and ryanodine (Rya) significantly reduced X/XO-induced rapid Ca2+ responses.”
“ Tetracaine (0·75 mM) caused transient complete inhibition of both local and propagating Ca2+ signals , followed by full recovery of the responses due to increased SR Ca2+ accumulation.”
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