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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Temozolomide
supplement:
Apigenin
Research Papers that Mention the Interaction
“Combining API and TMZ significantly induced glioma cells arrest at the G2 phase and inhibited glioma cells proliferation compared with API or TMZ alone.”
“Combining API and TMZ significantly inhibited the protein expression of p-AKT, cyclin D1, Bcl-2, Matrix Metallopeptidase 2, and Matrix Metallopeptidase 9.”
“Conclusion: API and TMZ synergistically inhibited glioma growth through the PI3K/AKT pathway.”
“Furthermore, compared with treatment with individual agents, the combination of API and TMZ significantly inhibited the growth of subcutaneous tumors in mice.”
“In addition, API promoted the ability of TMZ to induce glioma cells apoptosis and inhibit glioma cells invasion.”
“These results implied that API could synergistically suppress the growth of glioma cells when combined with TMZ.”
Apigenin and Temozolomide Synergistically Inhibit Glioma Growth Through the PI3K/AKT Pathway.
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